Literally! With Rob Lowe Creators & Guests

Robert Hepler Lowe is an American actor and director. He made his acting debut at the age of 15 with ABC's short-lived sitcom A New Kind of Family (1979-1980). He worked in the first four seasons of NBC's The West Wing and recently starred in later seasons of Parks and Recreation.

Lily Jane Collins is an English-American actress, model, and writer. The daughter of English musician Phil Collins, and an American mother, Jill Tavelman, she was born in Surrey and moved to Los Angeles as a child.

Kevin Dillon is an actor. He was nominated for three Primetime Emmy Awards and a Golden Globe Award for his performance on Entourage.

Tig Notaro is an American stand-up comedian, writer, and actress known for her deadpan delivery and autobiographical humor. She gained widespread acclaim with her 2012 stand-up album Live, which was recorded shortly after her cancer diagnosis. Notaro has since become a prominent figure in comedy, receiving Grammy and Emmy nominations for her specials. She starred in and co-created the semi-autobiographical series One Mississippi (2015-2017) and has had roles in films such as Army of the Dead (2021). Notaro is also known for her podcast Tig and Cheryl: True Story and for being a prominent advocate for LGBTQ+ visibility.

Jim Gaffigan is an American stand-up comedian, actor, and writer. Born in Elgin, Illinois, Gaffigan has built a successful career by focusing on everyday topics like food, parenting, and the mundane aspects of life. Gaffigan has released numerous successful stand-up specials, including Mr. Universe (2012), Obsessed (2014), Cinco (2017), and Quality Time (2019), which have all earned Grammy nominations. In addition to his stand-up, he has appeared in films such as Super Troopers (2001) and Chappaquiddick (2017), and he starred in The Jim Gaffigan Show (2015–2016), a semi-autobiographical sitcom. Gaffigan is also a best-selling author, with books like Dad Is Fat (2013) and Food: A Love Story (2014).

Paul Andrew Richter, commonly known as Andy Richter, was born on October 28, 1966 in Grand Rapids, MI. Andy is an American actor, comedian, writer, and talk show announcer. He is best known as the sidekick for Conan O'Brien on each of O'Brien's talk shows: Late Night and The Tonight Show on NBC and Conan on TBS. He was also star of the TV series Andy Richter Controls the Universe. He also hosts “The Three Questions” for O'Brien's podcast company, Team Coco.

Jamie Kern Lima is an entrepreneur, philanthropist, speaker, former journalist, and co-founder & CEO of IT Cosmetics.

Julian Edelman is a football wide receiver and punt returner for the New England Patriots of the NFL.

Fred Armisen, born December 4, 1966, is an American actor, comedian, writer, producer, and musician known for his versatile and eclectic performances. He rose to fame as a cast member on "Saturday Night Live" (2002-2013), where his wide range of impressions and characters made him a standout. Armisen co-created and starred in the acclaimed sketch comedy series "Portlandia" (2011-2018), which earned him a Peabody Award and multiple Emmy nominations. He has also appeared in various television shows and films, including "Documentary Now!" and "Forever." Armisen is a talented musician, serving as the bandleader for the "Late Night with Seth Meyers" house band, The 8G Band. His contributions to comedy and entertainment are celebrated for their originality and impact.

William Shatner is an actor, author, producer, director, and singer.

Iliza Shlesinger is a comedian, winner of NBC's Last Comic Standing, and went on to host the syndicated dating show Excused as well as the TBS comedy & game show Separation Anxiety. She briefly hosted her own late-night talk show called Truth & Iliza on Freeform and currently hosts the Ask Iliza Anything Podcast.

Sofía Vergara is a Colombian-American actress, television producer, and businesswoman who rose to fame with her role as Gloria Delgado-Pritchett on the ABC hit sitcom Modern Family (2009–2020), earning her multiple Primetime Emmy and Golden Globe nominations. She has also been a co-host on America's Got Talent since 2020. One of the highest-paid actresses in Hollywood, Vergara has built a successful career in both English and Spanish-language television and film, with notable roles in Chef (2014) and Hot Pursuit (2015).

Richard Lewis Springthorpe is known professionally as Rick Springfield. He is an Australian musician and actor.

Malcolm Gladwell is a Canadian journalist, author, and public speaker known for his books and essays on social science, psychology, and human behavior. He has been a staff writer for New Yorker since 1996. Gladwell gained widespread recognition with his debut book, "The Tipping Point," followed by bestsellers like "Blink," "Outliers," and "David and Goliath." He is also the co-founder of the podcast company Pushkin Industries and hosts the "Revisionist History" podcast.

Penn Dayton Badgley is an American actor and musician.

Oprah Winfrey is a media executive, actor, talk show host, television producer, and philanthropist. She is best known for her talk show "The Oprah Winfrey Show," which aired nationally for 25 years. Winfrey is currently the host of multiple shows, including ''Oprah Super Soul', 'The Oprah Winfrey Show: The Podcast' and 'Oprah's Master Class: The Podcast'.

Katie Couric is a journalist and author.

Jerry O'Connell is an American actor and television host.

Jonathan Edward Bernthal is an actor. He was cast as Frank Cast, punisher as part of the Netflix MCU web series. He debuted on Daredevil before starring in his own titular series The Punisher.